Title of article
Towards novel amide-modified oligonucleotides: asymmetric synthesis of 5′-(S)-methyl-3′-carboxymethylene-3′-deoxythymidine
Author/Authors
Wendeborn، نويسنده , , Sebastian and Nussbaumer، نويسنده , , Hannes and Robert، نويسنده , , Frédéric and Jِrg، نويسنده , , Mario and Pachlatko، نويسنده , , Johannes Paul، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
5461
To page
5464
Abstract
The synthesis of novel 5′-(S)-methyl-3′-carboxymethylene-3′-deoxythymidine is reported. Key steps involve diastereoselective lactonization, enantioselective enzymatic ester hydrolysis and diastereoselective glycosidation of a key intermediate with thymine with 100% β-selectivity via Lewis acid mediated cleavage of a [3.2.1] oxabicyclic lactone.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1652926
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