Regioselective and diastereoselective phosphine-catalysed [3+2] cycloadditions to 5-methylenehydantoins: reversal of regioselectivity using chiral N-2-butynoyl-(4S)-benzyloxazolidinone
Author/Authors :
Pham، نويسنده , , Tien Q and Pyne، نويسنده , , Stephen G and Skelton، نويسنده , , Brian W and White، نويسنده , , Allan H، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Pages :
4
From page :
5953
To page :
5956
Abstract :
The phosphine-catalysed [3+2] cycloaddition of 5-methylenehydantoins 1 with the ylides 2a and 2b gives spirocyclic products with reverse regioselectivities; the latter ylide gives optically active products.
