Title of article
A simple and effective synthetic approach to chiral 4-pyridinyl proline derivatives
Author/Authors
Priem، نويسنده , , Ghislaine and Anson، نويسنده , , Mike S. and Macdonald، نويسنده , , Simon J.F. and Pelotier، نويسنده , , Béatrice and Campbell، نويسنده , , Ian B.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
6001
To page
6003
Abstract
A rapid approach has been developed to provide a novel series of 4-pyridinyl proline derivatives as potential stereoselective catalysts. Nucleophilic displacement at the 4-pyridinyl position proved straightforward using proline but required microwave heating to proceed when using the more bulky α-methyl proline. Total control of enantioselectivity was obtained for the synthesis of proline derivatives.
Keywords
chiral catalysts , PPY , DMAP , 4-pyridinyl proline
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1653270
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