Title of article :
Synthesis of 2-amino-6-(2-[18F]fluoro-pyridine-4-ylmethoxy)-9-(octyl-β-d-glucosyl)-purine: a novel radioligand for positron emission tomography studies of the O6-methylguanine-DNA methyltransferase (MGMT) status of tumour tissue
Author/Authors :
Schirrmacher، نويسنده , , Ralf and Mühlhausen، نويسنده , , Ute and Wنngler، نويسنده , , Bjِrn and Schirrmacher، نويسنده , , Esther and Reinhard، نويسنده , , Jost and Nagel، نويسنده , , Gerd and Kaina، نويسنده , , Bernd and Piel، نويسنده , , Markus and Wieكler، نويسنده , , Manfred and Rِsch، نويسنده , , Frank، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Pages :
4
From page :
6301
To page :
6304
Abstract :
The synthesis of the novel glucose conjugated O6-methylguanine-DNA methyltransferase (MGMT) inhibitor 2-amino-6-(2-[18F]fluoro-pyridine-4-ylmethoxy)-9-(octyl-α-d-glucosyl)-purine is reported. This compound might serve as a radiotracer for the determination of the MGMT status of tumour tissue.
Keywords :
Positron emission tomography , mgmt , 18F-fluorination
Journal title :
Tetrahedron Letters
Serial Year :
2002
Journal title :
Tetrahedron Letters
Record number :
1653479
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1653479
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