Title of article :
A short synthesis of the C15–C21 segment of (+)-discodermolide, based on an asymmetric approach from achiral 2-methyl-1,3-propanediol to versatile enantiopure stereotriads
Author/Authors :
Shahid، نويسنده , , Kazi A. and Li، نويسنده , , Yong-Nan and Okazaki، نويسنده , , Momotoshi and Shuto، نويسنده , , Yoshihiro and Goto، نويسنده , , Fumitaka and Kiyooka، نويسنده , , Syun-ichi، نويسنده ,
Abstract :
A new approach was developed to versatile enantiopure stereotriads using chiral oxazaborolidinone-promoted asymmetric aldol reaction of a racemic aldehyde with a bromo silyl nucleophile. A short synthesis of the C15–C21 segment of (+)-discodermolide was achieved by elongation of one of the stereotriads with further diastereoselective aldol reaction with the same nucleophile.
