Title of article
A short synthesis of the C15–C21 segment of (+)-discodermolide, based on an asymmetric approach from achiral 2-methyl-1,3-propanediol to versatile enantiopure stereotriads
Author/Authors
Shahid، نويسنده , , Kazi A. and Li، نويسنده , , Yong-Nan and Okazaki، نويسنده , , Momotoshi and Shuto، نويسنده , , Yoshihiro and Goto، نويسنده , , Fumitaka and Kiyooka، نويسنده , , Syun-ichi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
6373
To page
6376
Abstract
A new approach was developed to versatile enantiopure stereotriads using chiral oxazaborolidinone-promoted asymmetric aldol reaction of a racemic aldehyde with a bromo silyl nucleophile. A short synthesis of the C15–C21 segment of (+)-discodermolide was achieved by elongation of one of the stereotriads with further diastereoselective aldol reaction with the same nucleophile.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1653526
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