Title of article :
Stereocontrolled synthesis of a potent agonist of group II metabotropic glutamate receptors, (+)-LY354740, and its related derivatives
Author/Authors :
Ohfune، نويسنده , , Yasufumi and Demura، نويسنده , , Takashi and Iwama، نويسنده , , Seiji and Matsuda، نويسنده , , Hiromi and Namba، نويسنده , , Kosuke and Shimamoto، نويسنده , , Keiko and Shinada، نويسنده , , Tetsuro، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
Efficient synthesis of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740: 1) and its structurally related analogs (−)-2 and (−)-3 has been accomplished starting with (1S,2R)-1-amino-2-hydroxycyclopentane- or cyclohexanecarboxylic acid (4 or 17 ) via an intramolecular cyclopropanation of α-diazo acetamide.
Keywords :
?-diazo acetamide , glutamate analog , mGluRs agonist , LY354740 , DCG-IV , l-CCG-III , transport inhibitor , dehydration
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
