• Title of article

    Do aziridines require Lewis acids for cleavage with ionic nucleophiles?

  • Author/Authors

    Bisai، نويسنده , , Alakesh and Pandey، نويسنده , , Ghanshyam N. Pandey، نويسنده , , Manoj P. and Singh، نويسنده , , Vinod K، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2003
  • Pages
    3
  • From page
    5839
  • To page
    5841
  • Abstract
    A variety of activated aziridines were cleaved by sodium azide and sodium cyanide in aqueous acetonitrile at reflux, in the absence of any Lewis acid, to provide ring-opened products in quantitative yields. However, the reaction was sluggish in the ring opening of unactivated aziridines with sodium azide where the yields could be increased by adding 50 mol% CuCl2·2H2O. The reaction was used to synthesize chiral diamines.
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2003
  • Journal title
    Tetrahedron Letters
  • Record number

    1653720