Title of article
Do aziridines require Lewis acids for cleavage with ionic nucleophiles?
Author/Authors
Bisai، نويسنده , , Alakesh and Pandey، نويسنده , , Ghanshyam N. Pandey، نويسنده , , Manoj P. and Singh، نويسنده , , Vinod K، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
5839
To page
5841
Abstract
A variety of activated aziridines were cleaved by sodium azide and sodium cyanide in aqueous acetonitrile at reflux, in the absence of any Lewis acid, to provide ring-opened products in quantitative yields. However, the reaction was sluggish in the ring opening of unactivated aziridines with sodium azide where the yields could be increased by adding 50 mol% CuCl2·2H2O. The reaction was used to synthesize chiral diamines.
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1653720
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