Title of article
Enantioselective synthesis of the carbacephem antibiotic loracarbef via Mitsunobu and Dieckmann cyclization from an unnatural amino acid
Author/Authors
Misner، نويسنده , , Jerry W and Fisher، نويسنده , , Jack W and Gardner، نويسنده , , John P and Pedersen، نويسنده , , Steve W and Trinkle، نويسنده , , Kristina L and Jackson، نويسنده , , Billy G and Zhang، نويسنده , , Tony Y، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
5991
To page
5993
Abstract
The nucleus of the carbacephem antibiotic loracarbef was synthesized in a highly efficient and enantioselective fashion from 2S,3S-2-amino-3-hydroxy-6-heptenoic acid (AHHA), which was derived from enzyme-catalyzed condensation of glycine and 4-pentenaldehyde. The bicyclic framework of this compound was established through sequential Mitsunobu reaction and aldol condensations.
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1653784
Link To Document