Author/Authors :
Misner، نويسنده , , Jerry W and Fisher، نويسنده , , Jack W and Gardner، نويسنده , , John P and Pedersen، نويسنده , , Steve W and Trinkle، نويسنده , , Kristina L and Jackson، نويسنده , , Billy G and Zhang، نويسنده , , Tony Y، نويسنده ,
Abstract :
The nucleus of the carbacephem antibiotic loracarbef was synthesized in a highly efficient and enantioselective fashion from 2S,3S-2-amino-3-hydroxy-6-heptenoic acid (AHHA), which was derived from enzyme-catalyzed condensation of glycine and 4-pentenaldehyde. The bicyclic framework of this compound was established through sequential Mitsunobu reaction and aldol condensations.
