Synthesis of peptide dendrimers based on a β-cyclodextrin core with guest binding ability

The synthesis of three first-order dendrimers based on a β-cyclodextrin core containing fourteen Val, Phe and Val-Phe residues is described. The guest binding ability of the tetradecavalent peptidyl β-cyclodextrin derivative has been tested by calorimetric titration and the thermodynamic parameters for the complex formation with adamantanecarboxylic acid were obtained.