Author/Authors :
Cainelli، نويسنده , , Gianfranco and Giacomini، نويسنده , , Daria and Gazzano، نويسنده , , Massimo and Galletti، نويسنده , , Paola and Quintavalla، نويسنده , , Arianna، نويسنده ,
Abstract :
This paper describes the different reactivity of E- and Z-4-alkylidene-β-lactams in acylation reactions under basic conditions. The E isomer is readily acylated, whereas the Z reacted sluggishly rearranging to the corresponding oxazin-6-one. The N-acylation of Z isomers was successfully obtained with oxalyl- or malonyl chlorides in benzene at reflux.
