Title of article
Synthesis of endogenous sperm-activating and attracting factor isolated from ascidian Ciona intestinalis
Author/Authors
Oishi، نويسنده , , Tohru and Tsuchikawa، نويسنده , , Hiroshi and Murata، نويسنده , , Michio and Yoshida، نويسنده , , Manabu and Morisawa، نويسنده , , Masaaki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
6387
To page
6389
Abstract
A chemoattractant candidate named sperm-activating and attracting factor (SAAF) from the eggs of ascidian Ciona intestinalis, was synthesized from chenodeoxycholic acid in 16 steps. The present synthesis led to the unambiguous structure determination of SAAF to be (3R,4R,7R,25S)-3,4,7,26-tetrahydroxycholestane-3,26-disulfate. The synthetic pure specimen was also used to confirm the dual sperm-activating and attracting activity.
Keywords
sterol disulfate , structure determination , Synthesis , sperm-activating and attracting factor
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1654017
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