Title of article
Total synthesis and determination of the absolute configuration of (+)-neoisoprelaurefucin
Author/Authors
Lee، نويسنده , , Hyunjoo and Kim، نويسنده , , Hyoungsu and Baek، نويسنده , , Seungyoup and Kim، نويسنده , , Sanghee and Kim، نويسنده , , Deukjoon Kim، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
6609
To page
6612
Abstract
The first total synthesis of the seven-membered ring ether marine natural product (+)-neoisoprelaurefucin (1) has been achieved employing a regioselective internal alkylation of amide 3, a novel sequence for removal of the triethylsilyl group from the resulting triethylsilyloxepene 2, and a bromoetherification of alcohol 16 as key steps. In addition, the absolute stereochemistry of the natural product was assigned.
Keywords
internal alkylation , total synthesis , Marine natural product , seven-membered ether ring
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1654197
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