Author/Authors :
M. Bashir-Uddin Surfraz، نويسنده , , M. and Miller، نويسنده , , David J. and Gani، نويسنده , , David and Allemann، نويسنده , , Rudolf K.، نويسنده ,
Abstract :
A series of product-like inhibitors of inositol monophosphatase have been prepared and tested for activity in vitro as possible leads for treatment of bipolar disorders. Compounds possessing a 6-alkyloxy side chain were inhibitors but less efficacious than those possessing a 6-aminoalkyl side chain. These new structures show promise as inhibitors possessing the bioavailability and characteristics necessary for drug development.
