Title of article
Dynamic kinetic resolution of α-bromo amides for asymmetric syntheses of di- and tripeptide analogues
Author/Authors
Nam، نويسنده , , Jiyoun and Chang، نويسنده , , Ji-Yeon and Hahm، نويسنده , , Kyung-Soo and Park، نويسنده , , Yong Sun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
7727
To page
7730
Abstract
Effective dynamic kinetic resolution in the nucleophilic substitution reactions of α-bromo amides derived from l-leucine and l-proline is described. The methodology is used with dibenzylamine as a nucleophile in the presence of TBAI and Et3N to provide di- and tripeptide analogues up to 95% yield and >99:1 dr.
Keywords
nucleophilic substitution , asymmetric syntheses , Peptidomimetics , dynamic kinetic resolution
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1655015
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