Author/Authors :
OʹNeil، نويسنده , , Ian A. and Thompson، نويسنده , , Stephen and Kalindjian، نويسنده , , S.Barret and Jenkins، نويسنده , , Terence C.، نويسنده ,
Abstract :
The novel C2-fluorinated pyrrolobenzodiazepines (1, 2 and 3) have been prepared from commercially available trans-hydroxyproline in good overall yield and were screened for in vitro cytotoxicity against a number of cancer cell lines. The 2R-fluoro isomer 2 exhibits an activity of 76 nM against the CH1 cell line.
