Title of article
The synthesis and biological activity of C2-fluorinated pyrrolo[2,1-c][1,4]benzodiazepines
Author/Authors
OʹNeil، نويسنده , , Ian A. and Thompson، نويسنده , , Stephen and Kalindjian، نويسنده , , S.Barret and Jenkins، نويسنده , , Terence C.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
7809
To page
7812
Abstract
The novel C2-fluorinated pyrrolobenzodiazepines (1, 2 and 3) have been prepared from commercially available trans-hydroxyproline in good overall yield and were screened for in vitro cytotoxicity against a number of cancer cell lines. The 2R-fluoro isomer 2 exhibits an activity of 76 nM against the CH1 cell line.
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1655067
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