A general and efficient route to enantioselective synthesis of pumiliotoxin A alkaloids via a common key intermediate

A general and efficient formal synthesis of pumiliotoxins and allopumiliotoxins has been achieved via a common key intermediate 3a. Our route featured a novel one-pot substitution–ring-opening sequence and an efficient Claisen-type condensation. This method is also applicable to quinolizidine derivative 2b.