Title of article :
Monitoring the synthetic procedures of commercial drugs by 2H NMR spectroscopy: The case of ibuprofen and naproxen
Author/Authors :
Acetti، نويسنده , , Daniela and Brenna، نويسنده , , Elisabetta and Fronza، نويسنده , , Giovanni and Fuganti، نويسنده , , Claudio، نويسنده ,
Issue Information :
ماهنامه با شماره پیاپی سال 2008
Abstract :
We determined the D/H isotope ratios of some ibuprofen and naproxen samples by 2H NMR spectroscopy. Some of these values were found to be useful for collecting hints on the synthetic procedures employed to prepare these drugs. Site-specific isotope ratio analysis shows great potentials in the fight against patent infringement.
Keywords :
Patent infringement , Naproxen , IBUPROFEN , Isotope ratio , NMR
