Author/Authors :
Bubenik، نويسنده , , Monica and Préville، نويسنده , , Patrice and Dugas، نويسنده , , Josée and Attardo، نويسنده , , Giorgio and Chan، نويسنده , , Laval، نويسنده ,
Abstract :
Recently we have reported a novel class of tetrahydrofuran phosphonates of which trans guanine nucleotide analog 1a showed potent antiviral activity as well as antitumor activity. In this paper we describe a stereoselective route where the key step involves an iodoetherification of a α-hydroxyphosphonate to generate the trans tetrahydrofuran with high stereoselectivity. The same intermediate 2 was also used to access the key intermediate for the cis analog 1b.
