Title of article :
A new synthetic entry to the tricyclic skeleton of FR901483 by palladium-catalyzed cyclization of vinyl bromides with ketone enolates
Author/Authors :
Bonjoch، نويسنده , , Josep and Diaba، نويسنده , , Fa??za and Puigb?، نويسنده , , Gemma and Peidr?، نويسنده , , Emma and Solé، نويسنده , , Daniel، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
A new synthetic entry to the FR901483 core is described. The Pd-mediated cyclization of amino-tethered vinyl halides and ketone enolates from the azaspiro[4.5]decan-8-ones 5 and 10 gives the functionalized 7,10a-methanoperhydropyrrolo[1,2-a]azocines 1 and 11, respectively.
Keywords :
Alkenylation , FR901483 , Nitrogen Heterocycles , PALLADIUM , spiro compounds
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
