Markedly chemoselective hydrogenation with retention of benzyl ester and N-Cbz functions using a heterogeneous Pd-fibroin catalyst

The chemoselective catalytic hydrogenation of acetylene, olefin and azido derivatives bearing benzyl ester and N-Cbz functionalities using a Pd-fibroin (Pd/Fib) catalyst was investigated. Perfect selectivity was accomplished, and the benzyl ester and N-Cbz functionalities are tolerated under the reaction conditions.