A concise synthesis of ortho-substituted aryl-acrylamides—potent activators of soluble guanylyl cyclase

Horner–Emmons reaction of phosphonate amides with aldehydes leads to generation of o-substituted aryl-acrylamides. These compounds have been shown to be useful to quickly establish structure–activity relationships (SAR) for soluble guanylyl cyclase (sGC) activator drug discovery.