Title of article
Highly diastereoselective nitroaldol reactions with chiral derivatives of glyoxylic acid
Author/Authors
Kudyba، نويسنده , , Iwona and Raczko، نويسنده , , Jerzy and Jurczak، نويسنده , , Janusz، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
8681
To page
8683
Abstract
N-Glyoxyloyl-(2R)-bornane-10,2-sultam (1a) and (1R)-8-phenylmenthyl glyoxylate (1b) react stereoselectively with simple nitroalkanes giving diastereomeric nitroalcohols with high asymmetric induction. The glyoximide 1a is proved to be a highly efficient chiral inducer, superior to glyoxylate 1b. In all cases, the absolute configuration (2S) and relative configuration, syn for the major diastereoisomers, were confirmed.
Keywords
nitroalcohols , Nitroaldol reaction , chiral auxiliary , Asymmetric induction
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1655675
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