• Title of article

    Synthesis of (−)-bestatin and the Taxotere® side-chain via nitroaldol reaction of (1R)-8-phenylmenthyl glyoxylate

  • Author/Authors

    Kudyba، نويسنده , , Iwona and Raczko، نويسنده , , Jerzy and Jurczak، نويسنده , , Janusz، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2003
  • Pages
    3
  • From page
    8685
  • To page
    8687
  • Abstract
    The nitroaldol reaction of (1R)-8-phenylmenthyl glyoxylate 6 with 1-nitro-2-phenylethane or with phenylnitromethane led stereoselectively to adducts 4 and 12, which where then transformed into (−)-bestatin hydrochloride and the Taxotere® side-chain in overall yields of 31 and 52%.
  • Keywords
    nitroalcohols , nitroaldol reactions , chiral auxiliary , Asymmetric induction
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2003
  • Journal title
    Tetrahedron Letters
  • Record number

    1655676

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1655676