Facile solid-phase synthesis of cyclic decapeptide antibiotic streptocidins A–D

Total synthesis of decapeptide antibiotics streptocidins A–D from Streptomyces sp. Tü 6071 was accomplished for the first time by solid-phase peptide synthesis followed by traceless cyclization of the activated linear precursors, without protection of nucleophilic side chain. Synthetic products were equally active as the natural products isolated from the bacterial source and found to possess similar bacterial selectivity as other members in the amphipathic antimicrobial cyclic decapeptide family.