Title of article
BH3 as a protecting group for phosphonic acid: a novel method for the synthesis of dinucleoside H-phosphonate
Author/Authors
Shimizu، نويسنده , , Mamoru and Tamura، نويسنده , , Kiyoshi and Wada، نويسنده , , Takeshi and Saigo، نويسنده , , Kazuhiko، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
371
To page
374
Abstract
A BH3 group is found to be an effective protecting group for phosphonic acid esters. This new phosphonic acid protecting group was applied to the synthesis of a dithymidine H-phosphonate derivative from a dithymidine boranophosphate derivative. Triarylmethyl cations were found to be effective for the deprotection of the BH3 group in the dithymidine boranophosphate diester to afford the corresponding H-phosphonate derivative in excellent yield.
Keywords
Protecting group , boranophosphate , H-phosphonate , Oligonucleotide synthesis , phosphonic acids
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1656401
Link To Document