Title of article
A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi
Author/Authors
Uchiyama، نويسنده , , Nahoko and Ito، نويسنده , , Michiho and Kiuchi، نويسنده , , Fumiyuki and Honda، نويسنده , , Gisho and Takeda، نويسنده , , Yoshio and Khodzhimatov، نويسنده , , Olimjon K. and Ashurmetov، نويسنده , , Ozodbek A. Ashurmetov، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
531
To page
533
Abstract
A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23 μM.
Keywords
Dracocephalum komarovi , Spiro lactone , Diterpene , trypanocidal activity , Trypanosoma cruzi
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1656515
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