Author/Authors :
Uchiyama، نويسنده , , Nahoko and Ito، نويسنده , , Michiho and Kiuchi، نويسنده , , Fumiyuki and Honda، نويسنده , , Gisho and Takeda، نويسنده , , Yoshio and Khodzhimatov، نويسنده , , Olimjon K. and Ashurmetov، نويسنده , , Ozodbek A. Ashurmetov، نويسنده ,
Abstract :
A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23 μM.
Keywords :
Dracocephalum komarovi , Spiro lactone , Diterpene , trypanocidal activity , Trypanosoma cruzi
