Palladium-catalysed amination of 2-acyl-1-alkyl-5-bromopyrroles

The first intermolecular C–N bond-forming reactions between substituted 2-bromopyrroles and primary and cyclic secondary amines were performed using Pd2(dba)3 as catalyst with BINAP as the ligand. The aminations proceeded in the presence of NaOtBu at 80–100 °C in 31–93% yields.