Title of article
Synthesis of methyleneaminodipeptides via ring opening of a 2-(t-butoxycarbonylmethyl)aziridine derivative
Author/Authors
Thierry، نويسنده , , Josiane and Servajean، نويسنده , , Vincent، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
821
To page
823
Abstract
The reactivity of 2-(t-butoxycarbonylmethyl)aziridine-1-carboxylic acid benzyl ester has been studied with various N-nucleophiles. The ring-opening reaction was always regioselective, the nucleophile attacking preferentially the less hindered carbon of the aziridine. The reaction was used to prepare a methyleneamino pseudodipeptide using the α-amine of a lysine ester.
Keywords
Aziridine opening , Lithium perchlorate , solvent-free reaction , Pseudopeptides methyleneamino , Microwaves
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1656703
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