Title of article :
Preparative-scale synthesis of both antipodes of B-γ,γ-dimethylallyldiisopinocampheylborane: application for the synthesis of C1–C6 subunit of epothilone
Author/Authors :
Ramachandran، نويسنده , , P.Veeraraghavan and Prabhudas، نويسنده , , Bodhuri and Chandra، نويسنده , , Subash C. Reddy، نويسنده , , M.Venkat Ram and Brown، نويسنده , , Herbert C.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
A preparative-scale synthesis of B-γ,γ-dimethylallyldiisopinocampheylborane starting from prenyl alcohol has been described. This reagent, upon reaction with various aldehydes, provides the corresponding α,α-dimethylhomoallylic alcohols in high enantioselectivities. The application of this reagent has been demonstrated for the synthesis of C1–C6 subunit of epothilone.
Keywords :
epothilone , Dimethylallylboration , Prenyl alcohol , B-Methoxydiisopinocampheylborane
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
