Synthesis of imidazole-4-carboxylic acids via solid-phase bound 3-N,N-(dimethylamino)-2-isocyanoacrylate

The novel 3-N,N-(dimethylamino)isocyanoacrylate-Wang-resin is used for the synthesis of imidazole-4-carboxylic acids. The syntheses are performed in a microwave reactor with reaction times of only 15 min at 220 °C in the solvent dimethoxyethane.