Author/Authors :
Pal، نويسنده , , Manojit and Parasuraman، نويسنده , , Karuppasamy and Subramanian، نويسنده , , Venkataraman and Dakarapu، نويسنده , , Rambabu and Yeleswarapu، نويسنده , , Koteswar Rao، نويسنده ,
Abstract :
The stereocontrolled synthesis of enynes has been accomplished via a sequential Heck–Sonogashira reaction in a simple synthetic operation. A variety of terminal alkynes were reacted with 3-iodo(thio)flavone in the presence of a palladium catalyst and a copper salt affording a mild and one-pot method for the first synthesis of the corresponding 3-enynyl and/or alkynyl derivatives. The mechanism and scope of the reaction are discussed.
Keywords :
palladium catalyst , Stereocontrolled synthesis , 3-Iodo(thio)flavone , 3-Enynyl/alkynyl thioflavones
