Title of article
Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues
Author/Authors
Fuwa، نويسنده , , Haruhiko and Okamura، نويسنده , , Yumiko and Morohashi، نويسنده , , Yuichi and Tomita، نويسنده , , Taisuke and Iwatsubo، نويسنده , , Takeshi and Kan، نويسنده , , Toshiyuki and Fukuyama، نويسنده , , Tohru and Natsugari، نويسنده , , Hideaki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
2323
To page
2326
Abstract
A highly efficient method for the synthesis of medium-sized lactams based on intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester has been developed. A variety of 7–10 membered lactams were synthesized in excellent yields. Application of the method to the synthesis of analogues of a potent γ-secretase inhibitor LY411575 and their biological evaluation are also described.
Keywords
Medium-sized lactams , Staudinger reaction , Aza-Wittig reaction , Structure–activity relationship , ?-Secretase inhibitor
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657548
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