Title of article
Dynamic kinetic resolution (DKR) using immobilized amine nucleophiles
Author/Authors
Valenrod، نويسنده , , Yevgeny and Myung، نويسنده , , Jinnie and Ben، نويسنده , , Robert N، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
2545
To page
2549
Abstract
The first example of a dynamic kinetic resolution (DKR) using immobilized amine nucleophiles is described. This approach utilizes a nucleophilic amine attached to a solid phase resin via an organic spacer. The optical purities of the N-substituted α-amino ester products are superior to the solution phase DKR with diastereomeric ratios ranging from 11:1 to 18:1 and chemical yields between 66% and 98%.
Keywords
dynamic kinetic resolution , solid phase , Immobilized amine , Resin-bound amine
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657662
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