Title of article
Synthesis of C4-linked imidazole ribonucleoside phosphoramidite with pivaloyloxymethyl (POM) group
Author/Authors
Araki، نويسنده , , Lisa and Harusawa، نويسنده , , Shinya and Yamaguchi، نويسنده , , Maho and Yonezawa، نويسنده , , Sumi and Taniguchi، نويسنده , , Natsumi and Lilley، نويسنده , , David M.J. and Zhao، نويسنده , , Zheng-yun and Kurihara، نويسنده , , Takushi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
2657
To page
2661
Abstract
A novel C4-linked imidazole ribonucleoside phosphoramidite was designed and successfully synthesized starting from tribenzylribofuranosylimidazole. This phosphoramidite product enables incorporation of the imidazole moiety into an RNA sequence and hence allows study of its role in the general acid and base catalysis of ribozymes. Pivaloyloxymethyl (POM) was first introduced as an N-protecting group for the imidazole ribonucleoside that can be readily removed under mild basic condition.
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657715
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