Title of article
Stereochemical assignment of the fungal metabolite xestodecalactone A by total synthesis
Author/Authors
Bringmann، نويسنده , , Gerhard and Lang، نويسنده , , Gerhard and Michel، نويسنده , , Manuela and Heubes، نويسنده , , Markus، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
2829
To page
2831
Abstract
The first synthesis of the macrocyclic natural product xestodecalactone A, a metabolite of a sponge-derived fungus, is described. By the use of methyl 5-hydroxyhexanoate in its R- or S-configured form, or as its racemate as the precursors, both enantiomers of xestodecalactone A as well as the racemic compound were obtained. Comparison of these synthetic products with the natural product by circular dichroism (CD) spectroscopy and by HPLC on a chiral phase revealed the natural product to have the (R)-configuration.
Keywords
absolute configuration , natural products , Chiral phase , circular dichroism spectroscopy , Xestodecalactones , total synthesis
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657798
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