Title of article
Novel anionic polycyclisation cascade. Highly stereocontrolled assembly of functionalised tetracycles akin to the middle core of the manzamines
Author/Authors
Turet، نويسنده , , Laurent and Markَ، نويسنده , , Istvلn E. and Tinant، نويسنده , , Bernard and Declercq، نويسنده , , Jean-Paul and Touillaux، نويسنده , , Rolland، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
5
From page
6591
To page
6595
Abstract
Substituted gramines, in the presence of tBuOK, react with acrolein and β-keto-phosphonates, via a novel sequence involving a multicomponent condensation followed by an anionic polycyclisation cascade, to afford in excellent overall yields, highly functionalised tetracyclic structures akin to the middle core of the manzamines. In this unique process, up to eight elementary transformations take place with remarkably high chemo- and stereocontrol.
Keywords
anionic polycyclisation , manzamines , perhydroisoquinoline , stereocontrol , ?-keto-phosphonates
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1657970
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