Author/Authors :
Marson، نويسنده , , Charles M. and Khan، نويسنده , , Afzal and Porter، نويسنده , , Rod A. and Cobb، نويسنده , , Alexander J.A. Cobb، نويسنده ,
Abstract :
Ketones are converted with very high stereocontrol into functionalised medium rings incorporating a β-hydroxy ketone assembly via a ring-expansion mediated by tin(IV) chloride at low temperatures; either the threo or the erythro aldol products can be obtained. An asymmetric epoxidation permitted a subsequent highly enantiocontrolled semi-pinacol rearrangement.
