Title of article
A new and efficient synthesis of (−)-indolizidine 167B by tandem metathesis
Author/Authors
Zaminer، نويسنده , , Jan and Stapper، نويسنده , , Christian and Blechert، نويسنده , , Siegfried، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
6739
To page
6741
Abstract
An enantioselective synthesis of the natural alkaloid (−)-indolizidine 167B is described. From an easily accessible chiral cycloheptene derivative a 2,5-dihydropyrrolidine was formed via a ruthenium-catalysed tandem ring-rearrangement metathesis. Annellation of the second ring was effected by an intramolecular reductive amination step under complete stereocontrol. (−)-Indolizidine 167B was obtained in 35% overall yield and high optical purity.
Keywords
asymmetric synthesis , Rearrangement , Ruthenium , Heterocycles
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1658064
Link To Document