Title of article
Methyl 3,3-difluoro-2-trimethylsilyloxyacrylate: preparation and Mukaiyama-type aldol condensation as a novel route to β,β-difluoro-α-keto ester derivatives
Author/Authors
Jiang، نويسنده , , Biao and Zhang، نويسنده , , Xiaobing and Shi، نويسنده , , Guoqiang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
6819
To page
6821
Abstract
Mukaiyama-type aldol condensation of arylaldehyde acetals occurs smoothly with methyl 3,3-difluoro-2-trimethylsilyloxyacrylate (derived from ethyl 3,3-difluoro-2-benzoylacrylate) when catalyzed by a Lewis acid, allowing preparation of 4-alkyloxy-3,3-difluoro-2-keto esters in high yields.
Keywords
Mukaiyama-type aldol condensation , Lewis acid , fluoro-keto-ester , fluorosiloxyacrylate
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1658123
Link To Document