Title of article
The first total synthesis of goniothalesdiol
Author/Authors
Babjak، نويسنده , , Matej and Kapitلn، نويسنده , , Peter and Gracza، نويسنده , , Tibor، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
6983
To page
6985
Abstract
The first total synthesis of goniothalesdiol, a dihydroxylated tetrahydrofuran isolated from Goniothalamus borneensis (Annonaceae), and its 7-epimer is described starting with d-mannitol. The key step of these syntheses is palladium(II)-catalyzed oxycarbonylation of unsaturated triols with d-lyxo and d-xylo configuration, respectively, which allowed efficient construction of the tetrahydrofuran ring with excellent threo-selectivity at the newly formed stereogenic centre.
Keywords
natural products , palladium(II) catalysis , stereoselective oxycarbonylation , goniothalesdiol
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1658191
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