• Title of article

    Synthesis of 2,5-dihalothiazole-4-carboxylates

  • Author/Authors

    Okonya، نويسنده , , John F and Al-Obeidi، نويسنده , , Fahad، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2002
  • Pages
    3
  • From page
    7051
  • To page
    7053
  • Abstract
    An efficient synthesis of 2,5-dihalothiazole-4-carboxylates has been described. Halogenation of aminothiazole carboxylate with NBS or NCS and subsequent diazotization with isoamyl nitrite and halogenation with CuBr2, CuCl2 or CH2I2 provided the corresponding diahalothiazole derivatives. The four-step process described is amenable to scale-up and requires no chromatographic purification in all the steps.
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2002
  • Journal title
    Tetrahedron Letters
  • Record number

    1658242

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1658242