Author/Authors :
Tice، نويسنده , , Colin M. and Michelotti، نويسنده , , Enrique L. and Mata، نويسنده , , Ernesto G. and Nicolàs، نويسنده , , Ernesto and Garcia Agreda، نويسنده , , Javier and Albericio، نويسنده , , Fernando، نويسنده ,
Abstract :
α-Acylamino-α,α-disubstituted ketones are of interest as ecdysone agonists. Solid phase synthesis of prototypical α-acylamino-α,α-disubstituted ketones on two different solid supports is described. In both cases the ketone was formed by reaction of a Grignard reagent with an N-acyl-α,α-disubstituted amino acid immobilized through its carboxylate as a Weinreb amide derivative.
