Combined solid phase and solution synthesis of a library of α,α-disubstituted-α-acylaminoketones

Preparation of a demonstration library of α,α-disubstituted-α-acylaminoketones, of interest as ecdysone agonists, is described. The five-step synthetic sequence employed α,α-disubstituted amino acids, Grignard reagents and carboxylic acids as building blocks in a strategic combination of solid phase and solution steps.