Title of article
Isoquinolinone synthesis by SNAr reaction: a versatile route to imidazo[4,5-h]isoquinolin-9-ones
Author/Authors
Snow، نويسنده , , Roger J. and Butz، نويسنده , , Tanja and Hammach، نويسنده , , Abdelhakim and Kapadia، نويسنده , , Suresh and Morwick، نويسنده , , Tina M. and Prokopowicz III، نويسنده , , Anthony S. and Takahashi، نويسنده , , Hidenori and Tan، نويسنده , , Jonathan D. and Tschantz، نويسنده , , Matt A. and Wang، نويسنده , , Xiao-Jun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
7553
To page
7556
Abstract
Reaction of 2-chlorobenzonitriles with β-ketoesters in an SNAr reaction, followed by cyclization in acid provides a versatile route to isoquinolones. Starting from 2,6-dichloro-3-nitrobenzonitrile 7, sequential displacement of the chlorines by an amine and a β-ketoester leads to imidazo[4,5-h]isoquinolin-9-ones 1, a new class of kinase inhibitor.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1658532
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