Author/Authors :
Rivas، نويسنده , , Lucrecia and Quintero، نويسنده , , Leticia and Fourrey، نويسنده , , Jean-Louis and Benhida، نويسنده , , Rachid، نويسنده ,
Abstract :
A short route to the marine natural product aspergillamide B has been developed. The key step is the stereoselective formation of the trans indole–enamide pharmacophore by indole-assisted dehydration from the functionalized aminoalcohol intermediate. HPLC and 1H NMR analyses show that aspergillamide B is more stable in the cis rotamer form.
