Author/Authors :
Bessières، نويسنده , , Bernard and Schoenfelder، نويسنده , , Angèle and Verrat، نويسنده , , Céline and Mann، نويسنده , , André and Ornstein، نويسنده , , Paul and Pedregal، نويسنده , , Conception، نويسنده ,
Abstract :
A general method based on the sequential reactivities of bis-bromocycloalkenes (3–5) is proposed for the preparation of phosphonocycloalkanes (1a/b–3a/b), representing structural constrained analogues of AP4. For the synthesis of an additional congested AP4 analogue (4), an intramolecular cyclopropanation of a ketocarbene towards a vinyphoshonate, assisted by Rh(OAc)2 was successfully experimented.
