Author/Authors :
Bleicher، نويسنده , , Konrad H. and Gerber، نويسنده , , Fernand and Wüthrich، نويسنده , , Yves and Alanine، نويسنده , , Alexander and Capretta، نويسنده , , Alfredo، نويسنده ,
Abstract :
Substituted imidazoles can be prepared efficiently from cyclic or acyclic 1,2-aminoalcohols via a four-step procedure involving acylation of the amine, oxidation of the alcohol, imine formation and cyclization. Examples are presented and the methodology is applied in the generation of a library of compounds containing a fused imidazole-azepine motif.
