Novel epoxidation reaction of perfluoroalkenes with trimethylamine N-oxide and iodosylbenzene

Trimethylamine N-oxide and iodosylbenzene were found to be useful reagents for the epoxidation of tri- and tetra-substituted perfluoroalkenes in good to excellent yields. A catalytic epoxidation method was also developed by coupling this reaction with the N-oxidation of trimethylamine by hydrogen peroxide or perbenzoic acid.