Title of article :
Enantioselective synthesis of NK-1 receptor antagonists (+)-CP-99,994 and (+)-CP-122,721
Author/Authors :
Yamazaki، نويسنده , , Naoki and Atobe، نويسنده , , Masakazu and Kibayashi، نويسنده , , Chihiro، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
An enantioselective total synthesis of NK-1 receptor antagonists, (+)-CP-99,994 and (+)-CP-122,721, is described. The key steps are diastereoselective addition of vinyllithium to a chiral benzaldehyde oxime ether and diastereoselective borane reduction of a cyclic oxime ether.
Keywords :
chiral oxime ethers , NK-1 receptor antagonist , CP-122 , 994 , 721 , CP-99
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
