Author/Authors :
Blass، نويسنده , , Benjamin E and Coburn، نويسنده , , Keith R and Faulkner، نويسنده , , Amy E. and Liu، نويسنده , , Song and Ogden، نويسنده , , Adam and Portlock، نويسنده , , David E and Srivastava، نويسنده , , Anil، نويسنده ,
Abstract :
The solid supported synthesis of functionalized 1,2,4-triazin-6-ones from resin bound amino acids and acid chlorides is described. A thioamide intermediate is generated with Lawessonʹs reagent, and the final products are cyclized and cleaved from resin with hydrazine. The products are obtained in good yield and purity.
Keywords :
solid-phase synthesis , 1 , 2 , 4-triazin-6-ones , Lawessonיs reagent
